Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2A All Species: 47.58
Human Site: T1014 Identified Species: 74.76
UniProt: P11388 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11388 NP_001058.2 1531 174385 T1014 G C L K K Y D T V L D I L R D
Chimpanzee Pan troglodytes XP_516332 1634 184611 T1043 G C L K K Y E T V Q D I L K E
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 T1029 G C L K K Y E T V Q D I L K E
Dog Lupus familis XP_537646 1532 174610 T1014 G C L K K Y D T V L D I L R D
Cat Felis silvestris
Mouse Mus musculus Q01320 1528 172859 T1013 G C L K K Y D T V L D I L R D
Rat Rattus norvegicus P41516 1526 173202 T1012 G C L K K Y D T V L D I L R D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519680 1746 195650 T1042 G C L K K Y D T A L D I L R D
Chicken Gallus gallus O42130 1553 174974 S1015 G F L K K Y E S P Q D I L K E
Frog Xenopus laevis NP_001082502 1579 178601 T1012 G C L R K Y E T V L D I L R E
Zebra Danio Brachydanio rerio NP_001003834 1574 177254 S1017 G S L K K Y E S V Q D I L K E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 T996 N C L R R F P T A I D I L K E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 S1050 G C L R T Y T S P E A I T Q E
Sea Urchin Strong. purpuratus XP_783546 1448 163750 V996 D T T V K F V V K M N E D R L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 T1004 G V I K K Y V T P E Q I L E E
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 M975 S P I S L M N M V A F D P H G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67.2 67.5 93.6 N.A. 89 88.7 N.A. 71.3 76.3 70.7 67.9 N.A. 51.2 N.A. 53 58.9
Protein Similarity: 100 78.6 78.4 96.4 N.A. 93.6 93.2 N.A. 79.1 85 81.8 78.8 N.A. 66.8 N.A. 70.4 73.4
P-Site Identity: 100 73.3 73.3 100 N.A. 100 100 N.A. 93.3 53.3 80 60 N.A. 40 N.A. 33.3 13.3
P-Site Similarity: 100 93.3 93.3 100 N.A. 100 100 N.A. 93.3 80 100 86.6 N.A. 80 N.A. 60 33.3
Percent
Protein Identity: N.A. N.A. N.A. 45 42.2 N.A.
Protein Similarity: N.A. N.A. N.A. 61.4 60.4 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 14 7 7 0 0 0 0 % A
% Cys: 0 67 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 0 34 0 0 0 74 7 7 0 34 % D
% Glu: 0 0 0 0 0 0 34 0 0 14 0 7 0 7 54 % E
% Phe: 0 7 0 0 0 14 0 0 0 0 7 0 0 0 0 % F
% Gly: 80 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 14 0 0 0 0 0 0 7 0 87 0 0 0 % I
% Lys: 0 0 0 67 80 0 0 0 7 0 0 0 0 34 0 % K
% Leu: 0 0 80 0 7 0 0 0 0 40 0 0 80 0 7 % L
% Met: 0 0 0 0 0 7 0 7 0 7 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 7 0 0 0 7 0 0 0 0 % N
% Pro: 0 7 0 0 0 0 7 0 20 0 0 0 7 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 27 7 0 0 7 0 % Q
% Arg: 0 0 0 20 7 0 0 0 0 0 0 0 0 47 0 % R
% Ser: 7 7 0 7 0 0 0 20 0 0 0 0 0 0 0 % S
% Thr: 0 7 7 0 7 0 7 67 0 0 0 0 7 0 0 % T
% Val: 0 7 0 7 0 0 14 7 60 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 80 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _